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Recent Publications

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Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption. Robinson SL, Bendrath SC, Yates EM, Thiele TE.Neuropsychopharmacology. 2024 Mar;49(4):690-698. doi: 10.1038/s41386-023-01742-w. Epub 2023 Sep 27.

Orexinergic lateral hypothalamus (LH) projections to medial septum (MS) modulate ethanol-induced sedation in male and female mice and binge-like ethanol drinking in male mice only.                                                                                                                                                     Bendrath SC, Cook CA, Knapp DJ, Thiele TE.Alcohol. 2024 Mar;115:13-22. doi: 10.1016/j.alcohol.2023.09.003. Epub 2023 Sep 15.PMID: 37717641

Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA. Dornellas APS, Thiele TE, Navarro M.Neuropharmacology. 2024 Feb 15;244:109809. doi: 10.1016/j.neuropharm.2023.109809. Epub 2023 Dec 3.

Somatostatin signaling modulates binge drinking behavior via the central nucleus of the amygdala.
Robinson SL, Thiele TE.Neuropharmacology. 2023 Jun 10:109622. doi: 10.1016/j.neuropharm.2023.109622.

Astrocyte expression in the extended amygdala of C57BL/6J mice is sex-dependently affected by chronic intermittent and binge-like ethanol exposure.
Brewton HW, Robinson SL, Thiele TE.Alcohol. 2023 May;108:55-64.

Chemogenetic inhibition of corticotropin-releasing factor neurons in the central amygdala alters binge-like ethanol consumption in male mice.
Marshall SA, Robinson SL, Ebert SE, Companion MA, Thiele TE.Behav Neurosci. 2022 Dec;136(6):541-550. doi: 10.1037/bne0000522.

Neurocircuitry modulating drug and alcohol abuse: A preface.
Thiele TE, Roberto M.Neuropharmacology. 2022 Oct 1;217:109200. doi: 10.1016/j.neuropharm.2022.109200.

Lateral habenula-projecting central amygdala circuits expressing GABA and NPY Y1 receptor modulate binge-like ethanol intake in mice.
Companion MA, Gonzalez DA, Robinson SL, Herman MA, Thiele TE.Addict Neurosci. 2022 Sep;3:100019. doi: 10.1016/j.addicn.2022.100019.

Activation of locus coeruleus to rostromedial tegmental nucleus (RMTg) noradrenergic pathway blunts binge-like ethanol drinking and induces aversive responses in mice.
Dornellas APS, Burnham NW, Luhn KL, Petruzzi MV, Thiele TE, Navarro M.Neuropharmacology. 2021 Nov 1;199:108797. doi: 10.1016/j.neuropharm.2021.108797.

Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice.
Burnham NW, Chaimowitz CN, Vis CC, Segantine Dornellas AP, Navarro M, Thiele TE.Neuropharmacology. 2021 Sep 15;196:108702. doi: 10.1016/j.neuropharm.2021.108702.

Distinct and Overlapping Patterns of Acute Ethanol-Induced C-Fos Activation in Two Inbred Replicate Lines of Mice Selected for Drinking to High Blood Ethanol Concentrations. Robinson SL, Dornellas APS, Burnham NW, Houck CA, Luhn KL, Bendrath SC, Companion MA, Brewton HW, Thomas RD, Navarro M, Thiele TE. Brain Sci. 2020 Dec 15;10(12):988. doi: 10.3390/brainsci10120988.

A Preliminary, Open-Label Study of Naltrexone and Bupropion Combination Therapy for Treating Binge Drinking in Human Subjects. Walter TJ, Navarro M, Thiele TE, Pedersen C, Kampov-Polevoy A, Garbutt JC. Alcohol Alcohol. 2020 Feb 7;55(1):56-62. doi: 10.1093/alcalc/agz076.

A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders. Robinson SL, Thiele TE. Neuropharmacology. 2020 May 1;167:107983. doi: 10.1016/j.neuropharm.2020.107983.

The melanocortin system as a potential target for treating alcohol use disorders: A review of pre-clinical data. Lerma-Cabrera JM, Carvajal F, Garbutt JC, Navarro M, Thiele TE. Brain Res. 2020 Mar 1;1730:146628. doi: 10.1016/j.brainres.2019.146628.

Corticotropin Releasing Factor Type 1 and 2 Receptor Signaling in the Medial Prefrontal Cortex Modulates Binge-Like Ethanol Consumption in C57BL/6J Mice. Robinson SL, Perez-Heydrich CA, Thiele TE. Brain Sci. 2019 Jul 19;9(7). pii: E171. doi: 10.3390/brainsci9070171.

Bupropion, Alone and in Combination with Naltrexone, Blunts Binge-Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice. Navarro M, Luhn KL, Kampov-Polevoy AB, Garbutt JC, Thiele TE. Alcohol Clin Exp Res. 2019 Feb 28. doi: 10.1111/acer.13992. [Epub ahead of print]

Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. Robinson SL, Marrero IM, Perez-Heydrich CA, Sepulveda-Orengo MT, Reissner KJ, Thiele TE. Neuropsychopharmacology. 2019 Jan 7. doi: 10.1038/s41386-018-0310-7. [Epub ahead of print]

Assessment of ventral tegmental area-projecting GABAergic neurons from the bed nucleus of the stria terminalis in modulating binge-like ethanol intake. Companion MA, Thiele TE. Eur J Neurosci. 2018 Dec;48(11):3335-3343. doi: 10.1111/ejn.14222. Epub 2018 Nov 15.

Assessment of depression-like behavior and anhedonia after repeated cycles of binge-like ethanol drinking in male C57BL/6J mice. Olney JJ, Marshall SA, Thiele TE. Pharmacol Biochem Behav. 2018 May;168:1-7. doi: 10.1016/j.pbb.2018.03.006. Epub 2018 Mar 15.

Voluntary Binge-like Ethanol Consumption Site-specifically Increases c-Fos Immunoexpression in Male C57BL6/J Mice. Burnham NW, Thiele TE.  Neuroscience. 2017 Dec 26;367:159-168. doi: 10.1016/j.neuroscience.2017.10.027. Epub 2017 Oct 27.

The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-Like Ethanol Drinking Behavior. Olney JJ, Navarro M, Thiele TE. Alcohol Clin Exp Res. 2017 Mar;41(3):551-561. doi: 10.1111/acer.13336. Epub 2017 Feb 9.

Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala. Marshall SA, McKnight KH, Blose AK, Lysle DT, Thiele TE. J Neuroimmune Pharmacol. 2017 Jun;12(2):249-259. doi: 10.1007/s11481-016-9709-2. Epub 2016 Sep 17.

Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake. Rinker JA, Marshall SA, Mazzone CM, Lowery-Gionta EG, Gulati V, Pleil KE, Kash TL, Navarro M, Thiele TE. Biol Psychiatry. 2016 Mar 3. pii: S0006-3223(16)30006-3. doi: 10.1016/j.biopsych.2016.02.029.

Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli. Navarro M, Olney JJ, Burnham NW, Mazzone CM, Lowery-Gionta EG, Pleil KE, Kash TL, Thiele TE. Neuropsychopharmacology. 2015 Oct 7. doi: 10.1038/npp.2015.304.

IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice. Marshall SA, Casachahua JD, Rinker JA, Blose AK, Lysle DT, Thiele TE.   Brain Behav Immun. 2015 Sep 10. pii: S0889-1591(15)30013-1. doi: 10.1016/j.bbi.2015.09.006.

Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE. Alcohol Clin Exp Res. 2015 Aug;39(8):1425-33. doi: 10.1111/acer.12774. Epub 2015 Jun 24.

Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice. Sprow GM, Rinker JA, Lowery-Gointa EG, Sparrow AM, Navarro M, Thiele TE. Addict Biol. 2015 May 15. doi: 10.1111/adb.12264.

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL. Nat Neurosci. 2015 Apr;18(4):545-52. doi: 10.1038/nn.3972. Epub 2015 Mar 9.